MolNFT v1 · #111023 · protein

The crystal structure of the G45V mutant of human glnrs

4YE9 · Glutamine--tRNA ligase: “The crystal structure of the G45V mutant of human glnrs”. X-ray diffraction, 7 pockets (best druggability 0.69). MolNFT v1 #111023 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4YE9
Type: protein
Length: 709 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutamine--tRNA ligase
EC: 6.1.1.18
UniProt: P47897
Pockets: 7 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutamine--tRNA ligase (EC 6.1.1.18)	protein	709	36% helix, 15% strand	P47897

Pockets

7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	601	0.69	0.78	49	empty
2	338	0.63	0.79	49	empty
3	56	0.56	0.89	15	empty
4	313	0.55	0.75	30	empty
5	66	0.51	0.85	22	empty

Compared structures

4YE9 · The crystal structure of the G45V mutant of human GlnRS · the same entry in another collection · chain A against A, TM-score 1.00
P47897 · AlphaFold monomer V2.0 prediction for glutamine--tRNA ligase (P47897) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P47897
Elsewhere: RCSB PDB 4YE9 · PDBe 4YE9 · UniProt P47897

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.