MolNFT v1 · #11100 · protein

Trpc stability mutant containing an engineered disulphide bridge and in complex with a cdrp-related substrate

1JCM · Indole-3-glycerol-phosphate synthase: “Trpc stability mutant containing an engineered disulphide bridge and in complex with a cdrp-related substrate”. X-ray diffraction, 2 ligands (137, PO4), 1 pocket (best druggability 0.80).…

PDB: 1JCM
Type: protein
Length: 259 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Indole-3-glycerol-phosphate synthase
EC: 4.1.1.48
Ligands: 137, PO4
Pockets: 1 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
P	Indole-3-glycerol-phosphate synthase (EC 4.1.1.48)	protein	259	40% helix, 19% strand	—

Ligands and binding sites

137 · 1-(O-carboxy-phenylamino)-1-deoxy-D-ribulose-5-phosphate · ligand · chains P
PO4 · Phosphate ion · ion · 6 copies · chains P

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	181	0.80	0.95	32	137

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1JCM · Trpc stability mutant containing an engineered disulphide bridge and in complex with a… · the same entry in another collection · chain P against P, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1JCM · PDBe 1JCM

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