MolNFT v1 · #110988 · protein
Bardet-biedl syndrome 9 protein (AA1-407), homo sapiens
4YD8 · Protein PTHB1: “Bardet-biedl syndrome 9 protein (AA1-407), homo sapiens”. X-ray diffraction, 7 pockets (best druggability 0.71). MolNFT v1 #110988 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4YD8
- Type
- protein
- Length
- 680 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein PTHB1
- UniProt
- Q3SYG4
- Pockets
- 7 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 3% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein PTHB1 | protein | 346 | 3% helix, 51% strand | Q3SYG4 |
| B | Protein PTHB1 | protein | 334 | 4% helix, 52% strand | Q3SYG4 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 696 | 0.71 | 0.77 | 72 | empty |
| 2 | 731 | 0.71 | 0.77 | 69 | empty |
| 3 | 437 | 0.62 | 0.76 | 71 | empty |
| 4 | 51 | 0.36 | 0.80 | 18 | empty |
| 5 | 76 | 0.36 | 0.77 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1716 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 20 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3SYG4
- Elsewhere: RCSB PDB 4YD8 · PDBe 4YD8 · UniProt Q3SYG4
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