MolNFT v1 · #110946 · protein
Structure of the human TSG101-uev domain in the P321 space group
4YC1 · Tumor susceptibility gene 101 protein: “Structure of the human TSG101-uev domain in the P321 space group”. X-ray diffraction, 1 ligand (SO4), 6 pockets (best druggability 0.72). MolNFT v1 #110946 on GenesisL1: 3D structure, binding…
- PDB
- 4YC1
- Type
- protein
- Length
- 440 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tumor susceptibility gene 101 protein
- UniProt
- Q99816
- Ligands
- SO4
- Pockets
- 6 · best druggability 0.72
Structure
x-ray diffraction · 3 distinct chains · 26% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tumor susceptibility gene 101 protein | protein | 148 | 26% helix, 31% strand | Q99816 |
| B | Tumor susceptibility gene 101 protein | protein | 149 | 25% helix, 32% strand | Q99816 |
| C | Tumor susceptibility gene 101 protein | protein | 143 | 27% helix, 32% strand | Q99816 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 5 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 657 | 0.72 | 0.79 | 63 | empty |
| 2 | 576 | 0.62 | 0.74 | 49 | empty |
| 3 | 284 | 0.54 | 0.76 | 31 | empty |
| 4 | 71 | 0.39 | 0.78 | 15 | empty |
| 5 | 66 | 0.37 | 0.78 | 17 | empty |
Interfaces
2 interfaces between chains.
- A–B · 688 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 525 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 4YC1 · Structure of the human TSG101-UEV domain in the P321 space group · the same entry in another collection · chain A against A, TM-score 1.00
- Q99816 · AlphaFold monomer V2.0 prediction for tumor susceptibility gene 101 protein (Q99816) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99816
- Elsewhere: RCSB PDB 4YC1 · PDBe 4YC1 · UniProt Q99816
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