MolNFT v1 · #110624 · protein

M300V 3D polymerase mutant of emcv

4Y2C · Genome polyprotein: “M300V 3D polymerase mutant of emcv”. X-ray diffraction, 2 pockets (best druggability 0.74). MolNFT v1 #110624 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4Y2C
Type: protein
Length: 460 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Genome polyprotein
EC: 3.6.1.15, 3.4.22.28, 2.7.7.48
UniProt: P12296
Pockets: 2 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Genome polyprotein (EC 3.6.1.15, 3.4.22.28, 2.7.7.48)	protein	460	41% helix, 16% strand	P12296

Ligands and binding sites

GOL · Glycerol · additive · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1014	0.74	0.77	73	GOL
2	164	0.56	0.81	34	empty

Compared structures

4Y2C · M300V 3D polymerase mutant of EMCV · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P12296
Elsewhere: RCSB PDB 4Y2C · PDBe 4Y2C · UniProt P12296

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