MolNFT v1 · #110546 · protein

KIF2C short LOOP2 construct

4Y05 · Kinesin-like protein KIF2C: “KIF2C short LOOP2 construct”. X-ray diffraction, 3 ligands (ADP, MG, SO4), 2 pockets (best druggability 0.45). MolNFT v1 #110546 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4Y05
Type: protein
Length: 330 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Kinesin-like protein KIF2C
UniProt: Q99661
Ligands: ADP, MG, SO4
Pockets: 2 · best druggability 0.45

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Kinesin-like protein KIF2C	protein	330	35% helix, 28% strand	Q99661

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · chains A
MG · Magnesium ion · metal · chains A
SO4 · Sulfate ion · ion · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	115	0.45	0.78	20	empty
2	76	0.44	0.81	19	empty

Compared structures

4Y05 · KIF2C short Loop2 construct · the same entry in another collection · chain A against A, TM-score 1.00
Q99661 · AlphaFold monomer V2.0 prediction for kinesin-like protein KIF2C (Q99661) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99661
Elsewhere: RCSB PDB 4Y05 · PDBe 4Y05 · UniProt Q99661

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