MolNFT v1 · #110523 · protein

Crystal structure of hiran domain of human hltf

4XZG · Helicase-like transcription factor: “Crystal structure of hiran domain of human hltf”. X-ray diffraction, 16 pockets (best druggability 0.70). MolNFT v1 #110523 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4XZG
Type: protein
Length: 1,093 residues
Chains: 9
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Helicase-like transcription factor
UniProt: Q14527
Pockets: 16 · best druggability 0.70

Structure

x-ray diffraction · 5 distinct chains · 23% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, D, E	Helicase-like transcription factor	protein	121	23% helix, 40% strand	Q14527
C	Helicase-like transcription factor	protein	120	23% helix, 38% strand	Q14527
F, I	Helicase-like transcription factor	protein	122	23% helix, 36% strand	Q14527
G	Helicase-like transcription factor	protein	123	23% helix, 35% strand	Q14527
H	Helicase-like transcription factor	protein	122	23% helix, 35% strand	Q14527

Pockets

16 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	263	0.70	0.85	47	empty
2	230	0.65	0.83	33	empty
3	397	0.65	0.79	44	empty
4	461	0.63	0.76	54	empty
5	181	0.60	0.82	30	empty

Interfaces

15 interfaces between chains.

A–G · 524 Å² buried · 9 hydrogen bonds · protein-protein
B–H · 503 Å² buried · 10 hydrogen bonds · protein-protein
A–E · 431 Å² buried · 9 hydrogen bonds · protein-protein
C–I · 422 Å² buried · 10 hydrogen bonds · protein-protein
A–D · 384 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

4XZG · Crystal structure of HIRAN domain of human HLTF · the same entry in another collection · chain I against I, TM-score 1.00
Q14527 · AlphaFold monomer V2.0 prediction for helicase-like transcription factor (Q14527) · a predicted model of the same protein · chain C against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14527
Elsewhere: RCSB PDB 4XZG · PDBe 4XZG · UniProt Q14527

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