MolNFT v1 · #11050 · protein

Crystal structure of NTF2 M118E mutant

1JB5 · Nuclear transport factor 2: “Crystal structure of NTF2 M118E mutant”. X-ray diffraction, 1 pocket (best druggability 0.40). MolNFT v1 #11050 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1JB5
Type: protein
Length: 246 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nuclear transport factor 2
UniProt: P61972
Pockets: 1 · best druggability 0.40

Structure

x-ray diffraction · 1 distinct chain · 28% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Nuclear transport factor 2	protein	123	28% helix, 51% strand	P61972

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	54	0.40	0.81	16	empty

Interfaces

1 interface between chains.

A–B · 1440 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

1JB5 · Crystal structure of NTF2 M118E mutant · the same entry in another collection · chain A against A, TM-score 1.00
P61972 · AlphaFold monomer V2.0 prediction for nuclear transport factor 2 (P61972) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P61972
Elsewhere: RCSB PDB 1JB5 · PDBe 1JB5 · UniProt P61972

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