MolNFT v1 · #11038 · protein
MMS2/UBC13 ubiquitin conjugating enzyme complex
1JAT · Ubiquitin-conjugating enzyme E2-17.5 kda: “MMS2/UBC13 ubiquitin conjugating enzyme complex”. X-ray diffraction, 1 pocket (best druggability 0.51). MolNFT v1 #11038 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1JAT
- Type
- protein
- Length
- 284 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin-conjugating enzyme E2-17.5 kda; Ubiquitin-conjugating enzyme variant MMS2
- EC
- 6.3.2.19
- UniProt
- P52490, P53152
- Pockets
- 1 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin-conjugating enzyme E2-17.5 kda (EC 6.3.2.19) | protein | 152 | 32% helix, 22% strand | P52490 |
| B | Ubiquitin-conjugating enzyme variant MMS2 | protein | 132 | 25% helix, 21% strand | P53152 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 190 | 0.51 | 0.77 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 766 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 1JAT · Mms2/Ubc13 Ubiquitin Conjugating Enzyme Complex · the same entry in another collection · chain A against A, TM-score 1.00
- P53152 · AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme variant MMS2 (P53152) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P52490 · AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 13 (P52490) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52490
- Every structure of UniProt P53152
- Elsewhere: RCSB PDB 1JAT · PDBe 1JAT · UniProt P52490 · UniProt P53152
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