MolNFT v1 · #110333 · protein
Structure of imp dehydrogenase of ashbya gossypii with imp bound to the active site
4XTI · Inosine-5'-monophosphate DEHYDROGENASE,INOSINE-5'…: “Structure of imp dehydrogenase of ashbya gossypii with imp bound to the active site”. X-ray diffraction, 2 ligands (IMP, K), 5 pockets (best druggability 0.72). MolNFT v1 #110333…
- PDB
- 4XTI
- Type
- protein
- Length
- 746 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inosine-5'-monophosphate DEHYDROGENASE,INOSINE-5'- monophosphate dehydrogenase
- EC
- 1.1.1.205
- UniProt
- Q756Z6
- Ligands
- IMP, K
- Pockets
- 5 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Inosine-5'-monophosphate DEHYDROGENASE,INOSINE-5'- monophosphate dehydrogenase (EC 1.1.1.205) | protein | 373 | 39% helix, 18% strand | Q756Z6 |
| B | Inosine-5'-monophosphate DEHYDROGENASE,INOSINE-5'- monophosphate dehydrogenase (EC 1.1.1.205) | protein | 373 | 38% helix, 18% strand | Q756Z6 |
Ligands and binding sites
- IMP · Inosinic acid · ligand · 2 copies · chains A, B
- K · Potassium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 339 | 0.72 | 0.85 | 39 | IMP |
| 2 | 348 | 0.72 | 0.84 | 41 | IMP |
| 3 | 906 | 0.71 | 0.76 | 70 | empty |
| 4 | 58 | 0.29 | 0.74 | 13 | empty |
| 5 | 63 | 0.27 | 0.73 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 133 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4XTI · Structure of IMP dehydrogenase of Ashbya gossypii with IMP bound to the active site · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q756Z6
- Elsewhere: RCSB PDB 4XTI · PDBe 4XTI · UniProt Q756Z6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.