MolNFT v1 · #110292 · protein
Crystal structure of sulfate TRANSPORTER/ANTISIGMA-factor antagonist stas from dyadobacter fermentans dsm 18053
4XS5: “Crystal structure of sulfate TRANSPORTER/ANTISIGMA-factor antagonist stas from dyadobacter fermentans dsm…”. X-ray diffraction, 4 pockets (best druggability 0.61). MolNFT v1 #110292 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4XS5
- Type
- protein
- Length
- 474 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sulfate TRANSPORTER/ANTISIGMA-factor antagonist stas
- UniProt
- C6VVE1
- Pockets
- 4 · best druggability 0.61
Structure
x-ray diffraction · 4 distinct chains · 46% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sulfate TRANSPORTER/ANTISIGMA-factor antagonist stas | protein | 119 | 47% helix, 18% strand | C6VVE1 |
| B | Sulfate TRANSPORTER/ANTISIGMA-factor antagonist stas | protein | 114 | 46% helix, 18% strand | C6VVE1 |
| C | Sulfate TRANSPORTER/ANTISIGMA-factor antagonist stas | protein | 122 | 46% helix, 19% strand | C6VVE1 |
| D | Sulfate TRANSPORTER/ANTISIGMA-factor antagonist stas | protein | 119 | 46% helix, 18% strand | C6VVE1 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 363 | 0.61 | 0.77 | 44 | empty |
| 2 | 289 | 0.56 | 0.77 | 31 | empty |
| 3 | 90 | 0.49 | 0.82 | 20 | empty |
| 4 | 134 | 0.48 | 0.79 | 33 | empty |
Interfaces
5 interfaces between chains.
- B–D · 555 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 469 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 377 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 254 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 123 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 13 modified (engineered).
Compared structures
- 4XS5 · Crystal structure of Sulfate transporter/antisigma-factor antagonist STAS from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C6VVE1
- Elsewhere: RCSB PDB 4XS5 · PDBe 4XS5 · UniProt C6VVE1
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