MolNFT v1 · #110089 · protein

Structure of chaetomium MEX67:MTR2 subunits

4XM4: “Structure of chaetomium MEX67:MTR2 subunits”. X-ray diffraction, 8 pockets (best druggability 0.73). MolNFT v1 #110089 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4XM4
Type: protein
Length: 663 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: MEX67
UniProt: G0SET4
Pockets: 8 · best druggability 0.73

Structure

x-ray diffraction · 4 distinct chains · 32% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	MEX67	protein	176	26% helix, 37% strand	G0SET4
B	MEX67	protein	183	24% helix, 36% strand	G0SET4
C	MEX67	protein	147	38% helix, 12% strand	G0SET4
D	MEX67	protein	157	44% helix, 11% strand	G0SET4

Pockets

8 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	471	0.73	0.82	34	empty
2	637	0.71	0.79	48	empty
3	52	0.71	0.99	19	empty
4	299	0.59	0.78	42	empty
5	131	0.54	0.81	21	empty

Interfaces

3 interfaces between chains.

A–B · 1921 Å² buried · 22 hydrogen bonds · protein-protein
A–C · 758 Å² buried · 11 hydrogen bonds · protein-protein
B–D · 611 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

4XM4 · Structure of Chaetomium Mex67:Mtr2 subunits · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0SET4
Elsewhere: RCSB PDB 4XM4 · PDBe 4XM4 · UniProt G0SET4

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