MolNFT v1 · #110041 · protein

Crystal structure of N-terminal domain of HSP90 from dictyostelium discoideum

4XKK · Heat shock cognate 90 kda protein: “Crystal structure of N-terminal domain of HSP90 from dictyostelium discoideum”. X-ray diffraction, 2 pockets (best druggability 0.66). MolNFT v1 #110041 on GenesisL1: 3D structure, binding sites…

PDB: 4XKK
Type: protein
Length: 215 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heat shock cognate 90 kda protein
UniProt: P54651
Pockets: 2 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heat shock cognate 90 kda protein	protein	215	43% helix, 23% strand	P54651

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	280	0.66	0.82	36	empty
2	51	0.28	0.75	10	empty

Compared structures

4XKK · Crystal structure of N-terminal domain of Hsp90 from Dictyostelium discoideum · the same entry in another collection · chain A against A, TM-score 1.00
P54651 · AlphaFold monomer V2.0 prediction for heat shock cognate 90 kda protein (P54651) · a predicted model of the same protein · chain A against A, TM-score 0.79

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P54651
Elsewhere: RCSB PDB 4XKK · PDBe 4XKK · UniProt P54651

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