MolNFT v1 · #110031 · protein

N-terminal domain of HSP90 from dictyostelium discoideum in hexagonal form with glycerol

4XKA · Heat shock cognate 90 kda protein: “N-terminal domain of HSP90 from dictyostelium discoideum in hexagonal form with glycerol”. X-ray diffraction, 1 ligand (TAM), 1 pocket (best druggability 0.64). MolNFT v1 #110031 on GenesisL1: 3D…

PDB: 4XKA
Type: protein
Length: 215 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heat shock cognate 90 kda protein
UniProt: P54651
Ligands: TAM
Pockets: 1 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heat shock cognate 90 kda protein	protein	215	42% helix, 22% strand	P54651

Ligands and binding sites

TAM · Tris(hydroxyethyl)aminomethane · ligand · chains A
GOL · Glycerol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	245	0.64	0.82	36	GOL

Compared structures

4XKA · N-terminal domain of Hsp90 from Dictyostelium discoideum in hexagonal form with glycerol · the same entry in another collection · chain A against A, TM-score 1.00
P54651 · AlphaFold monomer V2.0 prediction for heat shock cognate 90 kda protein (P54651) · a predicted model of the same protein · chain A against A, TM-score 0.80

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P54651
Elsewhere: RCSB PDB 4XKA · PDBe 4XKA · UniProt P54651

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