MolNFT v1 · #110026 · protein
Crystal structure of a PHOSPHOSERINE/PHOSPHOHYDROXYTHREONINE aminotransferase (psat) from pseudomonas aeruginosa with cofactor pyridoxal phosphate and bound glutamate
4XK1 · Phosphoserine aminotransferase: “Crystal structure of a PHOSPHOSERINE/PHOSPHOHYDROXYTHREONINE aminotransferase (psat) from pseudomonas…”. X-ray diffraction, 1 ligand (GLU), 11 pockets (best druggability 0.71). MolNFT v1 #110026 on…
- PDB
- 4XK1
- Type
- protein
- Length
- 702 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphoserine aminotransferase
- EC
- 2.6.1.52
- UniProt
- Q9HZ66
- Ligands
- GLU
- Pockets
- 11 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphoserine aminotransferase (EC 2.6.1.52) | protein | 355 | 42% helix, 16% strand | Q9HZ66 |
| B | Phosphoserine aminotransferase (EC 2.6.1.52) | protein | 347 | 41% helix, 17% strand | Q9HZ66 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 50 | 0.71 | 0.99 | 20 | empty |
| 2 | 263 | 0.62 | 0.81 | 47 | empty |
| 3 | 292 | 0.61 | 0.79 | 39 | empty |
| 4 | 126 | 0.56 | 0.83 | 20 | empty |
| 5 | 92 | 0.53 | 0.83 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 2058 Ų buried · 33 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (cofactor).
Compared structures
- 4XK1 · Crystal Structure of a Phosphoserine/phosphohydroxythreonine Aminotransferase (PSAT) from… · the same entry in another collection · chain B against B, TM-score 1.00
- Q9HZ66 · AlphaFold monomer V2.0 prediction for phosphoserine aminotransferase (Q9HZ66) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HZ66
- Elsewhere: RCSB PDB 4XK1 · PDBe 4XK1 · UniProt Q9HZ66
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