MolNFT v1 · #110024 · protein
Crystal structure of apo nanb sialidase from streptococcus pneumoniae at pH 7.4 in pbs with dmso
4XJZ · Sialidase B: “Crystal structure of apo nanb sialidase from streptococcus pneumoniae at pH 7.4 in pbs with dmso”. X-ray diffraction, 1 ligand (PO4), 6 pockets (best druggability 0.63). MolNFT v1 #110024 on GenesisL1: 3D structure…
- PDB
- 4XJZ
- Type
- protein
- Length
- 658 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sialidase B
- EC
- 3.2.1.18
- UniProt
- Q54727
- Ligands
- PO4
- Pockets
- 6 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 3% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sialidase B (EC 3.2.1.18) | protein | 658 | 3% helix, 45% strand | Q54727 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 369 | 0.63 | 0.78 | 39 | DMS |
| 2 | 344 | 0.62 | 0.79 | 28 | DMS |
| 3 | 196 | 0.50 | 0.76 | 32 | DMS |
| 4 | 208 | 0.48 | 0.75 | 23 | empty |
| 5 | 77 | 0.40 | 0.79 | 16 | empty |
Compared structures
- 4XJZ · Crystal structure of apo NanB sialidase from streptococcus pneumoniae at pH 7.4 in PBS… · the same entry in another collection · chain A against A, TM-score 1.00
- Q54727 · AlphaFold monomer V2.0 prediction for sialidase B (Q54727) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q54727
- Elsewhere: RCSB PDB 4XJZ · PDBe 4XJZ · UniProt Q54727
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.