MolNFT v1 · #109977 · protein

Crystal structure of apo nanb sialidase from streptococcus pneumoniae at pH 8.0 with mpd as the cryoprotectant

4XIO · Sialidase B: “Crystal structure of apo nanb sialidase from streptococcus pneumoniae at pH 8.0 with mpd as the cryoprotectant”. X-ray diffraction, 6 pockets (best druggability 0.62). MolNFT v1 #109977 on GenesisL1: 3D structure…

PDB: 4XIO
Type: protein
Length: 658 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sialidase B
EC: 3.2.1.18
UniProt: Q54727
Pockets: 6 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 3% helix, 45% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sialidase B (EC 3.2.1.18)	protein	658	3% helix, 45% strand	Q54727

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	303	0.62	0.80	35	empty
2	224	0.54	0.78	34	empty
3	229	0.52	0.76	39	empty
4	243	0.52	0.76	30	empty
5	57	0.33	0.77	14	empty

Compared structures

4XIO · Crystal structure of apo NanB sialidase from streptococcus pneumoniae at pH 8.0 with MPD… · the same entry in another collection · chain A against A, TM-score 1.00
Q54727 · AlphaFold monomer V2.0 prediction for sialidase B (Q54727) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q54727
Elsewhere: RCSB PDB 4XIO · PDBe 4XIO · UniProt Q54727

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