MolNFT v1 · #109941 · protein

Archaeoglobus fulgidus thioredoxin 3 M60H

4XHM · Thioredoxin (trx-3): “Archaeoglobus fulgidus thioredoxin 3 M60H”. X-ray diffraction, 1 pocket (best druggability 0.37). MolNFT v1 #109941 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4XHM
Type: protein
Length: 219 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Thioredoxin (trx-3)
UniProt: O28984
Pockets: 1 · best druggability 0.37

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Thioredoxin (trx-3)	protein	110	36% helix, 26% strand	O28984
B	Thioredoxin (trx-3)	protein	109	36% helix, 27% strand	O28984

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	60	0.37	0.80	17	empty

Interfaces

1 interface between chains.

A–B · 533 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

4XHM · Archaeoglobus fulgidus thioredoxin 3 M60H · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O28984
Elsewhere: RCSB PDB 4XHM · PDBe 4XHM · UniProt O28984

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