MolNFT v1 · #109721 · protein
Crystal structure of DSCAM1 isoform 4.4, N-terminal four ig domains
4XB7 · Down syndrome cell adhesion molecule, isoform 4.4: “Crystal structure of DSCAM1 isoform 4.4, N-terminal four ig domains”. X-ray diffraction, 2 ligands (NAG, BMA), 14 pockets (best druggability 0.83). MolNFT v1 #109721 on GenesisL1…
- PDB
- 4XB7
- Type
- protein
- Length
- 790 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Down syndrome cell adhesion molecule, isoform 4.4
- Ligands
- NAG, BMA
- Pockets
- 14 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 6% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Down syndrome cell adhesion molecule, isoform 4.4 | protein | 395 | 6% helix, 50% strand | — |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains A, B
- BMA · beta-D-mannopyranose · sugar · 3 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 778 | 0.83 | 0.87 | 96 | empty |
| 2 | 93 | 0.71 | 0.94 | 27 | empty |
| 3 | 154 | 0.70 | 0.89 | 31 | empty |
| 4 | 80 | 0.53 | 0.86 | 17 | empty |
| 5 | 90 | 0.46 | 0.80 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 2316 Ų buried · 26 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide, 4 glycan (disulfide, N-glycosylation).
Compared structures
- 4XB7 · Crystal structure of Dscam1 isoform 4.4, N-terminal four Ig domains · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4XB7 · PDBe 4XB7
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