MolNFT v1 · #109660 · protein
Crystal structure of DSCAM1 isoform 6.44, N-terminal four ig domains
4X9G · Down syndrome cell adhesion molecule isoform 6.44: “Crystal structure of DSCAM1 isoform 6.44, N-terminal four ig domains”. X-ray diffraction, 3 ligands (NAG, MAN, BMA), 8 pockets (best druggability 0.81). MolNFT v1 #109660 on…
- PDB
- 4X9G
- Type
- protein
- Length
- 780 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Down syndrome cell adhesion molecule isoform 6.44
- Ligands
- NAG, MAN, BMA
- Pockets
- 8 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 4% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Down syndrome cell adhesion molecule isoform 6.44 | protein | 390 | 4% helix, 48% strand | — |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains A, B
- MAN · alpha-D-mannopyranose · sugar · 6 copies · chains B, A
- BMA · beta-D-mannopyranose · sugar · 4 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 782 | 0.81 | 0.84 | 100 | empty |
| 2 | 205 | 0.70 | 0.87 | 43 | empty |
| 3 | 217 | 0.59 | 0.81 | 37 | empty |
| 4 | 77 | 0.49 | 0.83 | 20 | empty |
| 5 | 52 | 0.38 | 0.80 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 1723 Ų buried · 24 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide, 4 glycan (disulfide, N-glycosylation).
Compared structures
- 4X9G · Crystal structure of Dscam1 isoform 6.44, N-terminal four Ig domains · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4X9G · PDBe 4X9G
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