MolNFT v1 · #109611 · protein
Crystal structure of murine 7B4 Fab monoclonal antibody against ADAMTS5
4X80 · IGG1 7B4 Fab light chain: “Crystal structure of murine 7B4 Fab monoclonal antibody against ADAMTS5”. X-ray diffraction, 3 pockets (best druggability 0.59). MolNFT v1 #109611 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 4X80
- Type
- protein
- Length
- 436 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- IGG1 7B4 Fab light chain; IGG1 7B4 Fab heavy chain
- Pockets
- 3 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | IGG1 7B4 Fab light chain | protein | 213 | 5% helix, 51% strand | — |
| H | IGG1 7B4 Fab heavy chain | protein | 223 | 5% helix, 51% strand | — |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 366 | 0.59 | 0.76 | 38 | empty |
| 2 | 368 | 0.57 | 0.75 | 57 | empty |
| 3 | 117 | 0.42 | 0.76 | 19 | empty |
Interfaces
1 interface between chains.
- L–H · 1710 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 4X80 · Crystal Structure of murine 7B4 Fab monoclonal antibody against ADAMTS5 · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4X80 · PDBe 4X80
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