Cobk precorrin-6A reductase

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 22% strand (DSSP).

Ligands and binding sites

• NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
• 3Y8 · 3-[(1R,2S,3S,7S,11S,16S,17R,18R,19R)-2,7,12,18-tetrakis(2-hydroxy-2-oxoethyl)-3,13-bis(3-hydroxy-3-oxopropyl)-1,2,5,7,11,17-hexamethyl-17-(3-oxidanyl-3-oxidanylidene-prop-1-enyl)-3,6,8,10,15,16,18,19,21,24-decahydrocorrin-8-yl]propanoic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 3 modified, 1 disulfide (engineered, disulfide).

Compared structures

• 4X7G · CobK precorrin-6A reductase · the same entry in another collection · chain A against A, TM-score 1.00
• O68098 · AlphaFold monomer V2.0 prediction for precorrin-6A reductase (O68098) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O68098
• Elsewhere: RCSB PDB 4X7G · PDBe 4X7G · UniProt O68098