MolNFT v1 · #109512 · protein
Crystal structure of the full-length human mitochondrial cca-adding enzyme
4X4W · Cca tRNA nucleotidyltransferase 1, mitochondrial: “Crystal structure of the full-length human mitochondrial cca-adding enzyme”. X-ray diffraction, 2 ligands (CL, SO4), 8 pockets (best druggability 0.58). MolNFT v1 #109512 on…
- PDB
- 4X4W
- Type
- protein
- Length
- 795 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cca tRNA nucleotidyltransferase 1, mitochondrial
- EC
- 2.7.7.72
- UniProt
- Q96Q11
- Ligands
- CL, SO4
- Pockets
- 8 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cca tRNA nucleotidyltransferase 1, mitochondrial (EC 2.7.7.72) | protein | 398 | 54% helix, 10% strand | Q96Q11 |
| B | Cca tRNA nucleotidyltransferase 1, mitochondrial (EC 2.7.7.72) | protein | 397 | 54% helix, 9% strand | Q96Q11 |
Ligands and binding sites
- CL · Chloride ion · ion · 8 copies · chains A, B
- SO4 · Sulfate ion · ion · 5 copies · chains A, B
- GOL · Glycerol · additive · 6 copies · chains A, B
- FLC · Citrate anion · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 231 | 0.58 | 0.80 | 38 | SO4 |
| 2 | 185 | 0.54 | 0.79 | 28 | CL |
| 3 | 252 | 0.53 | 0.76 | 42 | CL |
| 4 | 249 | 0.50 | 0.75 | 32 | FLC, GOL |
| 5 | 244 | 0.48 | 0.74 | 25 | FLC, GOL |
Interfaces
1 interface between chains.
- A–B · 606 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 4X4W · Crystal structure of the full-length human mitochondrial CCA-adding enzyme · the same entry in another collection · chain A against A, TM-score 1.00
- Q96Q11 · AlphaFold monomer V2.0 prediction for cca tRNA nucleotidyltransferase 1, mitochondrial… · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96Q11
- Elsewhere: RCSB PDB 4X4W · PDBe 4X4W · UniProt Q96Q11
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.