MolNFT v1 · #10948 · protein

Crystal structure of a functional unit of interphotoreceptor retinoid-binding protein (irbp)

1J7X: “Crystal structure of a functional unit of interphotoreceptor retinoid-binding protein (irbp)”. X-ray diffraction, 3 pockets (best druggability 0.73). MolNFT v1 #10948 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1J7X
Type: protein
Length: 302 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interphotoreceptor retinoid-binding protein
UniProt: Q7SZI7
Pockets: 3 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Interphotoreceptor retinoid-binding protein	protein	302	37% helix, 20% strand	Q7SZI7

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	90	0.73	0.95	21	empty
2	196	0.46	0.74	28	empty
3	72	0.31	0.73	12	empty

Modifications

Observed in the structure: 4 modified (engineered).

Compared structures

1J7X · Crystal structure of a functional unit of interphotoreceptor retinoid-binding protein… · the same entry in another collection · chain A against A, TM-score 1.00
Q7SZI7 · AlphaFold monomer V2.0 prediction for retinol-binding protein 3 (Q7SZI7) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7SZI7
Elsewhere: RCSB PDB 1J7X · PDBe 1J7X · UniProt Q7SZI7

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