MolNFT v1 · #109436 · protein

SAC3N peptide bound to MEX67:MTR2

4X2O · Putative mRNA export protein: “SAC3N peptide bound to MEX67:MTR2”. X-ray diffraction, 2 pockets (best druggability 0.42). MolNFT v1 #109436 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4X2O
Type: protein
Length: 362 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative mRNA export protein; Putative uncharacterized protein; Putative SAC3 family…
UniProt: G0SET4, G0SG92
Pockets: 2 · best druggability 0.42

Structure

x-ray diffraction · 3 distinct chains · 27% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative mRNA export protein	protein	179	25% helix, 41% strand	G0SET4
B	Putative uncharacterized protein	protein	175	30% helix, 35% strand	G0SG92
C	Putative SAC3 family protein	protein	8	0% helix, 13% strand	—

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	122	0.42	0.76	25	empty
2	51	0.34	0.78	10	empty

Interfaces

2 interfaces between chains.

A–B · 1952 Å² buried · 34 hydrogen bonds · protein-protein
A–C · 474 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

4X2O · Sac3N peptide bound to Mex67:Mtr2 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0SET4
Every structure of UniProt G0SG92
Elsewhere: RCSB PDB 4X2O · PDBe 4X2O · UniProt G0SET4 · UniProt G0SG92

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.