MolNFT v1 · #109429 · protein

SAC3N peptide bound to MEX67:MTR2

4X2H · Putative mRNA export protein: “SAC3N peptide bound to MEX67:MTR2”. X-ray diffraction, 3 pockets (best druggability 0.54). MolNFT v1 #109429 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4X2H
Type: protein
Length: 373 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative mRNA export protein; Putative uncharacterized protein…
UniProt: G0SET4, G0SG92
Pockets: 3 · best druggability 0.54

Structure

x-ray diffraction · 3 distinct chains · 28% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative mRNA export protein	protein	192	29% helix, 36% strand	G0SET4
B	Putative uncharacterized protein	protein	175	27% helix, 35% strand	G0SG92
C	Ser-ser-val-phe-gly-ala-pro-ala	protein	6	0% helix, 17% strand	—

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	216	0.54	0.78	29	empty
2	215	0.49	0.75	36	empty
3	58	0.31	0.75	10	empty

Interfaces

2 interfaces between chains.

A–B · 1981 Å² buried · 38 hydrogen bonds · protein-protein
A–C · 488 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

4X2H · Sac3N peptide bound to Mex67:Mtr2 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0SET4
Every structure of UniProt G0SG92
Elsewhere: RCSB PDB 4X2H · PDBe 4X2H · UniProt G0SET4 · UniProt G0SG92

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