MolNFT v1 · #109396 · protein

X-ray crystal structure of the dimeric bmp antagonist NBL1

4X1J · Neuroblastoma suppressor of tumorigenicity 1: “X-ray crystal structure of the dimeric bmp antagonist NBL1”. X-ray diffraction, 1 ligand (NAG). MolNFT v1 #109396 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4X1J
Type: protein
Length: 177 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neuroblastoma suppressor of tumorigenicity 1
UniProt: P41271
Ligands: NAG

Structure

x-ray diffraction · 2 distinct chains · 0% helix, 68% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Neuroblastoma suppressor of tumorigenicity 1	protein	83	0% helix, 70% strand	P41271
B	Neuroblastoma suppressor of tumorigenicity 1	protein	94	0% helix, 66% strand	P41271

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 1163 Å² buried · 17 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 10 disulfide, 2 glycan (disulfide, N-glycosylation).

Compared structures

4X1J · X-ray crystal structure of the dimeric BMP antagonist NBL1 · the same entry in another collection · chain A against A, TM-score 1.00
P41271 · AlphaFold monomer V2.0 prediction for neuroblastoma suppressor of tumorigenicity 1… · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P41271
Elsewhere: RCSB PDB 4X1J · PDBe 4X1J · UniProt P41271

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