MolNFT v1 · #109360 · protein
Trypanosoma brucei haptoglobin-haemoglobin receptor
4X0J · Haptoglobin-hemoglobin receptor: “Trypanosoma brucei haptoglobin-haemoglobin receptor”. X-ray diffraction, 3 pockets (best druggability 0.58). MolNFT v1 #109360 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4X0J
- Type
- protein
- Length
- 523 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Haptoglobin-hemoglobin receptor
- UniProt
- I7BA99
- Pockets
- 3 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 86% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Haptoglobin-hemoglobin receptor | protein | 261 | 85% helix, 0% strand | I7BA99 |
| B | Haptoglobin-hemoglobin receptor | protein | 262 | 86% helix, 0% strand | I7BA99 |
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 318 | 0.58 | 0.77 | 47 | empty |
| 2 | 101 | 0.56 | 0.85 | 22 | empty |
| 3 | 187 | 0.50 | 0.77 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 1013 Ų buried · 22 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4X0J · Trypanosoma brucei haptoglobin-haemoglobin receptor · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt I7BA99
- Elsewhere: RCSB PDB 4X0J · PDBe 4X0J · UniProt I7BA99
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