MolNFT v1 · #109354 · protein + RNA
Structure of tRNA-processing enzyme complex 6
4X0A · Poly a polymerase: “Structure of tRNA-processing enzyme complex 6”. X-ray diffraction, 5 pockets (best druggability 0.78). MolNFT v1 #109354 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4X0A
- Type
- protein + RNA
- Length
- 440 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Poly a polymerase; RNA (73-mer)
- UniProt
- O66728
- Pockets
- 5 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 57% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Poly a polymerase | protein | 367 | 57% helix, 11% strand | O66728 |
| B | RNA (73-mer) | rna | 73 | — | — |
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 644 | 0.78 | 0.84 | 57 | empty |
| 2 | 668 | 0.72 | 0.80 | 48 | empty |
| 3 | 460 | 0.71 | 0.82 | 41 | empty |
| 4 | 391 | 0.59 | 0.77 | 24 | empty |
| 5 | 99 | 0.35 | 0.73 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 888 Ų buried · 8 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O66728
- Elsewhere: RCSB PDB 4X0A · PDBe 4X0A · UniProt O66728
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