MolNFT v1 · #109342 · protein + DNA
Crystal structure of human puf-a in complex with DNA
4WZW · Pumilio domain-containing protein KIAA0020: “Crystal structure of human puf-a in complex with DNA”. X-ray diffraction, 2 pockets (best druggability 0.81). MolNFT v1 #109342 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 4WZW
- Type
- protein + DNA
- Length
- 535 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pumilio domain-containing protein KIAA0020; DNA…
- UniProt
- Q15397
- Pockets
- 2 · best druggability 0.81
Structure
x-ray diffraction · 3 distinct chains · 70% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pumilio domain-containing protein KIAA0020 | protein | 505 | 70% helix, 0% strand | Q15397 |
| B | DNA (5'-D(P*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*G)-3') | dna | 14 | — | — |
| C | DNA (5'- D(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*C)-3') | dna | 16 | — | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1104 | 0.81 | 0.83 | 90 | empty |
| 2 | 80 | 0.33 | 0.74 | 15 | empty |
Interfaces
3 interfaces between chains.
- B–C · 662 Ų buried · 72 hydrogen bonds · nucleic-nucleic
- A–B · 393 Ų buried · 4 hydrogen bonds · protein-nucleic
- A–C · 297 Ų buried · 1 hydrogen bond · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15397
- Elsewhere: RCSB PDB 4WZW · PDBe 4WZW · UniProt Q15397
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