MolNFT v1 · #109337 · protein
Crystal structure of human puf-a
4WZR · Pumilio domain-containing protein KIAA0020: “Crystal structure of human puf-a”. X-ray diffraction, 7 pockets (best druggability 0.57). MolNFT v1 #109337 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4WZR
- Type
- protein
- Length
- 1,024 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pumilio domain-containing protein KIAA0020
- UniProt
- Q15397
- Pockets
- 7 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pumilio domain-containing protein KIAA0020 | protein | 511 | 74% helix, 0% strand | Q15397 |
| B | Pumilio domain-containing protein KIAA0020 | protein | 513 | 72% helix, 0% strand | Q15397 |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 360 | 0.57 | 0.75 | 47 | empty |
| 2 | 266 | 0.54 | 0.76 | 41 | empty |
| 3 | 110 | 0.44 | 0.78 | 21 | empty |
| 4 | 89 | 0.43 | 0.78 | 20 | empty |
| 5 | 63 | 0.38 | 0.78 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 577 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15397
- Elsewhere: RCSB PDB 4WZR · PDBe 4WZR · UniProt Q15397
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