MolNFT v1 · #109333 · protein + RNA
Mutant K18E of RNA dependent RNA polymerase from foot-and-mouth disease virus complexed with RNA
4WZM: “Mutant K18E of RNA dependent RNA polymerase from foot-and-mouth disease virus complexed with RNA”. X-ray diffraction, 1 ligand (MN), 4 pockets (best druggability 0.81). MolNFT v1 #109333 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4WZM
- Type
- protein + RNA
- Length
- 490 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA dependent RNA polymerase; RNA template; RNA primer
- EC
- 2.7.7.48
- UniProt
- P03311
- Ligands
- MN
- Pockets
- 4 · best druggability 0.81
Structure
x-ray diffraction · 3 distinct chains · 41% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA dependent RNA polymerase (EC 2.7.7.48) | protein | 475 | 41% helix, 17% strand | P03311 |
| B | RNA template | rna | 8 | — | — |
| C | RNA primer | rna | 7 | — | — |
Ligands and binding sites
- MN · Manganese (II) ion · metal · chains A
- GOL · Glycerol · additive · 2 copies · chains A
- ACT · Acetate ion · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1186 | 0.81 | 0.82 | 92 | ACT |
| 2 | 160 | 0.66 | 0.87 | 33 | empty |
| 3 | 63 | 0.49 | 0.85 | 16 | empty |
| 4 | 55 | 0.31 | 0.76 | 19 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1049 Ų buried · 30 hydrogen bonds · protein-nucleic
- A–C · 677 Ų buried · 8 hydrogen bonds · protein-nucleic
- B–C · 267 Ų buried · 21 hydrogen bonds · nucleic-nucleic
Compared structures
- 4WZM · Mutant K18E of RNA dependent RNA polymerase from Foot-and-Mouth Disease Virus complexed… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03311
- Elsewhere: RCSB PDB 4WZM · PDBe 4WZM · UniProt P03311
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.