MolNFT v1 · #109320 · protein
Human cftr AA389-678 (NBD1), DELTAF508 with three solubilizing mutations, bound ATP
4WZ6 · Cystic fibrosis transmembrane conductance regulator: “Human cftr AA389-678 (NBD1), DELTAF508 with three solubilizing mutations, bound ATP”. X-ray diffraction, 2 ligands (ATP, MG), 1 pocket (best druggability 0.55). MolNFT v1 #109320…
- PDB
- 4WZ6
- Type
- protein
- Length
- 258 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cystic fibrosis transmembrane conductance regulator
- EC
- 3.6.3.49
- UniProt
- P13569
- Ligands
- ATP, MG
- Pockets
- 1 · best druggability 0.55
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cystic fibrosis transmembrane conductance regulator (EC 3.6.3.49) | protein | 258 | 42% helix, 21% strand | P13569 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 116 | 0.55 | 0.83 | 35 | MG |
Compared structures
- 4WZ6 · Human CFTR aa389-678 (NBD1), deltaF508 with three solubilizing mutations, bound ATP · the same entry in another collection · chain A against A, TM-score 1.00
- P13569 · AlphaFold monomer V2.0 prediction for cystic fibrosis transmembrane conductance regulator… · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13569
- Elsewhere: RCSB PDB 4WZ6 · PDBe 4WZ6 · UniProt P13569
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