MolNFT v1 · #109318 · protein
Crystal structure of P. aeruginosa ampc
4WZ4 · Beta-lactamase: “Crystal structure of P. aeruginosa ampc”. X-ray diffraction, 1 ligand (3VU), 2 pockets (best druggability 0.58). MolNFT v1 #109318 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4WZ4
- Type
- protein
- Length
- 360 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-lactamase
- EC
- 3.5.2.6
- UniProt
- P24735
- Ligands
- 3VU
- Pockets
- 2 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta-lactamase (EC 3.5.2.6) | protein | 360 | 43% helix, 23% strand | P24735 |
Ligands and binding sites
- 3VU · {(3R)-6-[(3-amino-1,2,4-thiadiazol-5-yl)oxy]-1-hydroxy-4,5-dimethyl-1,3-dihydro-2,1-benzoxaborol-3-yl}acetic acid · ligand · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 313 | 0.58 | 0.77 | 41 | 3VU |
| 2 | 75 | 0.33 | 0.75 | 14 | empty |
Modifications
Observed in the structure: 1 covalent (covalent ligand).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24735
- Elsewhere: RCSB PDB 4WZ4 · PDBe 4WZ4 · UniProt P24735
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.