MolNFT v1 · #109312 · protein

Mutant K20E of 3D polymerase from foot-and-mouth disease virus

4WYW · RNA-directed RNA polymerase 3D-pol: “Mutant K20E of 3D polymerase from foot-and-mouth disease virus”. X-ray diffraction, 1 ligand (3PO), 4 pockets (best druggability 0.58). MolNFT v1 #109312 on GenesisL1: 3D structure, binding sites…

PDB: 4WYW
Type: protein
Length: 479 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-directed RNA polymerase 3D-pol
EC: 2.7.7.48
UniProt: P03311
Ligands: 3PO
Pockets: 4 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA-directed RNA polymerase 3D-pol (EC 2.7.7.48)	protein	479	40% helix, 19% strand	P03311

Ligands and binding sites

3PO · Triphosphate · ligand · chains A
GOL · Glycerol · additive · 4 copies · chains A
ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	384	0.58	0.75	34	3PO
2	278	0.56	0.77	31	ACT
3	108	0.34	0.72	19	empty
4	53	0.24	0.73	15	empty

Compared structures

4WYW · Mutant K20E of 3D polymerase from Foot-and-Mouth Disease Virus · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03311
Elsewhere: RCSB PDB 4WYW · PDBe 4WYW · UniProt P03311

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