MolNFT v1 · #109264 · protein
Drosophila muscle gluriib complex with glutamate
4WXJ · Glutamate receptor IIB,GLUTAMATE receptor iib: “Drosophila muscle gluriib complex with glutamate”. X-ray diffraction, 1 ligand (GLU), 3 pockets (best druggability 0.71). MolNFT v1 #109264 on GenesisL1: 3D structure, binding sites…
- PDB
- 4WXJ
- Type
- protein
- Length
- 506 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor IIB,GLUTAMATE receptor iib
- UniProt
- Q9VMP3
- Ligands
- GLU
- Pockets
- 3 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate receptor IIB,GLUTAMATE receptor iib | protein | 252 | 38% helix, 27% strand | Q9VMP3 |
| B | Glutamate receptor IIB,GLUTAMATE receptor iib | protein | 254 | 38% helix, 25% strand | Q9VMP3 |
Ligands and binding sites
- GLU · Glutamic acid · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 541 | 0.71 | 0.80 | 91 | empty |
| 2 | 66 | 0.36 | 0.78 | 17 | empty |
| 3 | 95 | 0.35 | 0.74 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1540 Ų buried · 39 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4WXJ · Drosophila muscle GluRIIB complex with glutamate · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9VMP3
- Elsewhere: RCSB PDB 4WXJ · PDBe 4WXJ · UniProt Q9VMP3
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