MolNFT v1 · #109258 · protein

Crystal structure of mycobacterium tuberculosis ogt-R37K

4WXD · Methylated-DNA--protein-cysteine methyltransferase: “Crystal structure of mycobacterium tuberculosis ogt-R37K”. X-ray diffraction, 3 pockets (best druggability 0.61). MolNFT v1 #109258 on GenesisL1: 3D structure, binding sites and…

PDB: 4WXD
Type: protein
Length: 165 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Methylated-DNA--protein-cysteine methyltransferase
EC: 2.1.1.63
UniProt: P9WJW5
Pockets: 3 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63)	protein	165	37% helix, 14% strand	P9WJW5

Ligands and binding sites

GOL · Glycerol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	202	0.61	0.82	28	GOL
2	55	0.32	0.77	16	GOL
3	57	0.27	0.73	14	empty

Compared structures

4WXD · Crystal structure of Mycobacterium tuberculosis OGT-R37K · the same entry in another collection · chain A against A, TM-score 1.00
P9WJW5 · AlphaFold monomer V2.0 prediction for methylated-DNA--protein- cysteine methyltransferase… · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P9WJW5
Elsewhere: RCSB PDB 4WXD · PDBe 4WXD · UniProt P9WJW5

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