MolNFT v1 · #109217 · protein

Double-heterohexameric rings of full-length RVB1(ADP)/RVB2(ADP)

4WW4 · Ruvb-like 1: “Double-heterohexameric rings of full-length RVB1(ADP)/RVB2(ADP)”. X-ray diffraction, 1 ligand (ADP), 12 pockets (best druggability 0.83). MolNFT v1 #109217 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4WW4
Type: protein
Length: 851 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ruvb-like 1; Ruvb-like 2
EC: 3.6.4.12
UniProt: G0RYI5, G0RYC2
Ligands: ADP
Pockets: 12 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ruvb-like 1 (EC 3.6.4.12)	protein	416	38% helix, 21% strand	G0RYI5
B	Ruvb-like 2 (EC 3.6.4.12)	protein	435	40% helix, 23% strand	G0RYC2

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	867	0.83	0.85	85	ADP
2	599	0.79	0.84	60	empty
3	174	0.69	0.88	27	ADP
4	363	0.60	0.76	42	empty
5	203	0.55	0.79	26	empty

Interfaces

1 interface between chains.

A–B · 2542 Å² buried · 23 hydrogen bonds · protein-protein

Compared structures

4WW4 · Double-heterohexameric rings of full-length Rvb1(ADP)/Rvb2(ADP) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0RYI5
Every structure of UniProt G0RYC2
Elsewhere: RCSB PDB 4WW4 · PDBe 4WW4 · UniProt G0RYI5 · UniProt G0RYC2

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