MolNFT v1 · #109204 · protein

Crystal structure of DSCAM1 IG7 domain, isoform 5

4WVR · Down syndrome cell adhesion molecule, isoform ak: “Crystal structure of DSCAM1 IG7 domain, isoform 5”. X-ray diffraction, 4 pockets (best druggability 0.62). MolNFT v1 #109204 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 4WVR
Type: protein
Length: 394 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Down syndrome cell adhesion molecule, isoform ak
UniProt: Q0E9K5
Pockets: 4 · best druggability 0.62

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, D	Down syndrome cell adhesion molecule, isoform ak	protein	98	6% helix, 49% strand	Q0E9K5
B, C	Down syndrome cell adhesion molecule, isoform ak	protein	99	6% helix, 48% strand	Q0E9K5

Pockets

4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	256	0.62	0.80	37	empty
2	281	0.56	0.77	33	empty
3	267	0.55	0.76	33	empty
4	317	0.53	0.74	35	empty

Interfaces

3 interfaces between chains.

A–D · 633 Å² buried · 17 hydrogen bonds · protein-protein
B–C · 632 Å² buried · 18 hydrogen bonds · protein-protein
C–D · 364 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

4WVR · Crystal structure of Dscam1 Ig7 domain, isoform 5 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q0E9K5
Elsewhere: RCSB PDB 4WVR · PDBe 4WVR · UniProt Q0E9K5

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