MolNFT v1 · #10919 · protein
Crystal structure of mutant macrophage capping protein (cap G) with actin-severing activity in the CA2+-free form
1J72: “Crystal structure of mutant macrophage capping protein (cap G) with actin-severing activity in the CA2+-free…”. X-ray diffraction, 4 pockets (best druggability 0.48). MolNFT v1 #10919 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1J72
- Type
- protein
- Length
- 337 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Macrophage capping protein
- UniProt
- P40121
- Pockets
- 4 · best druggability 0.48
Structure
x-ray diffraction · 1 distinct chain · 21% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Macrophage capping protein | protein | 337 | 21% helix, 30% strand | P40121 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 240 | 0.48 | 0.74 | 36 | empty |
| 2 | 148 | 0.46 | 0.77 | 27 | empty |
| 3 | 160 | 0.45 | 0.75 | 28 | empty |
| 4 | 69 | 0.34 | 0.76 | 15 | empty |
Compared structures
- 1J72 · Crystal Structure of Mutant Macrophage Capping Protein (Cap G) with Actin-severing… · the same entry in another collection · chain A against A, TM-score 1.00
- P40121 · AlphaFold monomer V2.0 prediction for macrophage-capping protein (P40121) · a predicted model of the same protein · chain A against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40121
- Elsewhere: RCSB PDB 1J72 · PDBe 1J72 · UniProt P40121
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