MolNFT v1 · #109185 · protein

Heat shock protein 70 substrate binding domain

4WV5 · Heat shock 70 kda protein 1A/1B: “Heat shock protein 70 substrate binding domain”. X-ray diffraction, 6 pockets (best druggability 0.51). MolNFT v1 #109185 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4WV5
Type: protein
Length: 279 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heat shock 70 kda protein 1A/1B
UniProt: P08107
Pockets: 6 · best druggability 0.51

Structure

x-ray diffraction · 2 distinct chains · 17% helix, 43% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heat shock 70 kda protein 1A/1B	protein	144	18% helix, 42% strand	P08107
B	Heat shock 70 kda protein 1A/1B	protein	135	16% helix, 44% strand	P08107

Ligands and binding sites

GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	117	0.51	0.81	19	GOL
2	207	0.50	0.76	28	empty
3	162	0.48	0.77	24	empty
4	89	0.40	0.77	20	empty
5	58	0.31	0.75	14	empty

Interfaces

1 interface between chains.

A–B · 701 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

4WV5 · Heat shock protein 70 substrate binding domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08107
Elsewhere: RCSB PDB 4WV5 · PDBe 4WV5 · UniProt P08107

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