MolNFT v1 · #10908 · protein

Crystal structure of activation (adomet binding) domain of methionine synthase (TM0269) from thermotoga maritima at 2.2 a resolution

1J6R: “Crystal structure of activation (adomet binding) domain of methionine synthase (TM0269) from thermotoga…”. X-ray diffraction, 9 pockets (best druggability 0.63). MolNFT v1 #10908 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 1J6R
Type: protein
Length: 394 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Methionine synthase
EC: 2.1.1.13
UniProt: Q9WYA6
Pockets: 9 · best druggability 0.63

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Methionine synthase (EC 2.1.1.13)	protein	197	43% helix, 17% strand	Q9WYA6

Pockets

9 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	260	0.63	0.81	30	empty
2	54	0.47	0.85	12	empty
3	80	0.44	0.80	13	empty
4	116	0.40	0.75	24	empty
5	84	0.39	0.77	16	empty

Interfaces

1 interface between chains.

A–B · 775 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

1J6R · Crystal structure of Activation (AdoMet binding) domain of Methionine synthase (TM0269)… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9WYA6
Elsewhere: RCSB PDB 1J6R · PDBe 1J6R · UniProt Q9WYA6

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