MolNFT v1 · #109033 · protein

Crystal structure of cytochrome P450 CYP107W1 from streptomyces avermitilis

4WPZ: “Crystal structure of cytochrome P450 CYP107W1 from streptomyces avermitilis”. X-ray diffraction, 2 ligands (HEM, K), 3 pockets (best druggability 0.80). MolNFT v1 #109033 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4WPZ
Type: protein
Length: 387 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytochrome P450
UniProt: Q93HJ0
Ligands: HEM, K
Pockets: 3 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 51% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cytochrome P450	protein	387	51% helix, 9% strand	Q93HJ0

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · chains A
K · Potassium ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1146	0.80	0.81	102	K, HEM
2	55	0.41	0.82	21	empty
3	63	0.31	0.75	16	empty

Modifications

Observed in the structure: 1 modified (oxidation).

Compared structures

4WPZ · Crystal structure of cytochrome P450 CYP107W1 from Streptomyces avermitilis · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q93HJ0
Elsewhere: RCSB PDB 4WPZ · PDBe 4WPZ · UniProt Q93HJ0

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