MolNFT v1 · #109031 · protein

Chaetomium theromophilum TREX2 cid domain complex

4WPX · Cell division control protein 31-like protein: “Chaetomium theromophilum TREX2 cid domain complex”. X-ray diffraction, 10 pockets (best druggability 0.74). MolNFT v1 #109031 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 4WPX
Type: protein
Length: 730 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cell division control protein 31-like protein; Putative SAC3 family protein; Putative…
UniProt: G0SAR7, G0SGL4, G0S6Y1
Pockets: 10 · best druggability 0.74

Structure

x-ray diffraction · 5 distinct chains · 63% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cell division control protein 31-like protein	protein	171	57% helix, 5% strand	G0SAR7
B, E	Putative SAC3 family protein	protein	81	89% helix, 0% strand	G0SGL4
C	Putative uncharacterized protein	protein	108	65% helix, 0% strand	G0S6Y1
D	Cell division control protein 31-like protein	protein	172	56% helix, 6% strand	G0SAR7
F	Putative uncharacterized protein	protein	117	66% helix, 3% strand	G0S6Y1

Pockets

10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	436	0.74	0.84	41	empty
2	180	0.54	0.79	22	empty
3	139	0.51	0.80	26	empty
4	157	0.46	0.76	19	empty
5	102	0.45	0.79	17	empty

Interfaces

10 interfaces between chains.

E–F · 1970 Å² buried · 6 hydrogen bonds · protein-protein
B–C · 1927 Å² buried · 10 hydrogen bonds · protein-protein
A–B · 1679 Å² buried · 16 hydrogen bonds · protein-protein
D–E · 1602 Å² buried · 14 hydrogen bonds · protein-protein
B–D · 328 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

4WPX · Chaetomium theromophilum TREX2 CID domain complex · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0SAR7
Every structure of UniProt G0SGL4
Every structure of UniProt G0S6Y1
Elsewhere: RCSB PDB 4WPX · PDBe 4WPX · UniProt G0SAR7 · UniProt G0SGL4 · UniProt G0S6Y1

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