MolNFT v1 · #109007 · protein
Chaetomium MEX67 uba domain
4WP2 · Putative mRNA export protein: “Chaetomium MEX67 uba domain”. X-ray diffraction, 11 pockets (best druggability 0.67). MolNFT v1 #109007 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4WP2
- Type
- protein
- Length
- 474 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative mRNA export protein
- UniProt
- G0SET4
- Pockets
- 11 · best druggability 0.67
Structure
x-ray diffraction · 3 distinct chains · 67% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, G | Putative mRNA export protein | protein | 61 | 67% helix, 3% strand | G0SET4 |
| B, D, H | Putative mRNA export protein | protein | 58 | 66% helix, 3% strand | G0SET4 |
| F | Putative mRNA export protein | protein | 56 | 68% helix, 4% strand | G0SET4 |
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 448 | 0.67 | 0.79 | 52 | empty |
| 2 | 149 | 0.55 | 0.81 | 24 | empty |
| 3 | 176 | 0.55 | 0.79 | 24 | empty |
| 4 | 144 | 0.48 | 0.78 | 21 | empty |
| 5 | 72 | 0.46 | 0.82 | 15 | empty |
Interfaces
13 interfaces between chains.
- E–F · 519 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 505 Ų buried · 3 hydrogen bonds · protein-protein
- G–H · 490 Ų buried · 3 hydrogen bonds · protein-protein
- F–G · 489 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 483 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified (artifact).
Compared structures
- 4WP2 · Chaetomium Mex67 UBA domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0SET4
- Elsewhere: RCSB PDB 4WP2 · PDBe 4WP2 · UniProt G0SET4
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