MolNFT v1 · #108977 · protein
Crystal structure of pyrococcus furiosus CMR4 (CAS7)
4WNZ · CRISPR system cmr subunit CMR4: “Crystal structure of pyrococcus furiosus CMR4 (CAS7)”. X-ray diffraction, 3 pockets (best druggability 0.55). MolNFT v1 #108977 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4WNZ
- Type
- protein
- Length
- 474 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CRISPR system cmr subunit CMR4
- UniProt
- Q8U1S9
- Pockets
- 3 · best druggability 0.55
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | CRISPR system cmr subunit CMR4 | protein | 237 | 31% helix, 28% strand | Q8U1S9 |
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 218 | 0.55 | 0.78 | 24 | empty |
| 2 | 227 | 0.55 | 0.78 | 30 | empty |
| 3 | 81 | 0.55 | 0.85 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 1356 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 4WNZ · Crystal structure of Pyrococcus furiosus Cmr4 (Cas7) · the same entry in another collection · chain A against A, TM-score 1.00
- Q8U1S9 · AlphaFold monomer V2.0 prediction for CRISPR system cmr endoribonuclease CMR4 (Q8U1S9) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8U1S9
- Elsewhere: RCSB PDB 4WNZ · PDBe 4WNZ · UniProt Q8U1S9
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