MolNFT v1 · #108958 · protein
Crystal structure of the tpr domain of lgn in complex with FRMPD4/PRESO1 at 2.1 ångström resolution
4WNG · G-protein-signaling modulator 2: “Crystal structure of the tpr domain of lgn in complex with FRMPD4/PRESO1 at 2.1 ångström resolution”. X-ray diffraction, 2 pockets (best druggability 0.37). MolNFT v1 #108958 on GenesisL1: 3D…
- PDB
- 4WNG
- Type
- protein
- Length
- 348 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- G-protein-signaling modulator 2; Ferm and PDZ domain-containing protein 4
- UniProt
- P81274, Q14CM0
- Pockets
- 2 · best druggability 0.37
Structure
x-ray diffraction · 2 distinct chains · 81% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | G-protein-signaling modulator 2 | protein | 330 | 85% helix, 0% strand | P81274 |
| B | Ferm and PDZ domain-containing protein 4 | protein | 18 | 0% helix, 0% strand | Q14CM0 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 113 | 0.37 | 0.74 | 19 | empty |
| 2 | 73 | 0.34 | 0.76 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1373 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 4WNG · Crystal structure of the TPR domain of LGN in complex with Frmpd4/Preso1 at 2.1 Angstrom… · the same entry in another collection · chain A against A, TM-score 1.00
- P81274 · AlphaFold monomer V2.0 prediction for G-protein-signaling modulator 2 (P81274) · a predicted model of the same protein · chain A against A, TM-score 0.96
- Q14CM0 · AlphaFold monomer V2.0 prediction for ferm and PDZ domain-containing protein 4 (Q14CM0) · a predicted model of the same protein · chain B against A, TM-score 0.24
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P81274
- Every structure of UniProt Q14CM0
- Elsewhere: RCSB PDB 4WNG · PDBe 4WNG · UniProt P81274 · UniProt Q14CM0
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