MolNFT v1 · #108874 · protein

Crystal structure of a conserved hypothetical protein from mycobacterium leprae determined by iodide sad phasing

4WKW · Uncharacterized protein: “Crystal structure of a conserved hypothetical protein from mycobacterium leprae determined by iodide sad…”. X-ray diffraction, 5 pockets (best druggability 0.61). MolNFT v1 #108874 on GenesisL1: 3D…

PDB: 4WKW
Type: protein
Length: 382 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uncharacterized protein
UniProt: B8ZRP7
Pockets: 5 · best druggability 0.61

Structure

x-ray diffraction · 2 distinct chains · 54% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uncharacterized protein	protein	197	54% helix, 11% strand	B8ZRP7
B	Uncharacterized protein	protein	185	54% helix, 11% strand	B8ZRP7

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	471	0.61	0.75	50	EDO
2	290	0.57	0.77	38	EDO
3	322	0.56	0.75	29	empty
4	61	0.29	0.75	17	empty
5	65	0.26	0.72	16	empty

Interfaces

1 interface between chains.

A–B · 465 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

4WKW · Crystal Structure of a Conserved Hypothetical Protein from Mycobacterium leprae… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B8ZRP7
Elsewhere: RCSB PDB 4WKW · PDBe 4WKW · UniProt B8ZRP7

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.