MolNFT v1 · #108825 · protein

Crystal structure of paxx

4WJA · Uncharacterized protein C9ORF142: “Crystal structure of paxx”. X-ray diffraction, 2 pockets (best druggability 0.51). MolNFT v1 #108825 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4WJA
Type: protein
Length: 258 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uncharacterized protein C9ORF142
UniProt: Q9BUH6
Pockets: 2 · best druggability 0.51

Structure

x-ray diffraction · 2 distinct chains · 34% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uncharacterized protein C9ORF142	protein	128	36% helix, 29% strand	Q9BUH6
B	Uncharacterized protein C9ORF142	protein	130	33% helix, 25% strand	Q9BUH6

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	284	0.51	0.74	39	empty
2	54	0.45	0.84	13	empty

Interfaces

1 interface between chains.

A–B · 642 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

4WJA · Crystal Structure of PAXX · the same entry in another collection · chain A against A, TM-score 1.00
Q9BUH6 · AlphaFold monomer V2.0 prediction for protein paxx (Q9BUH6) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9BUH6
Elsewhere: RCSB PDB 4WJA · PDBe 4WJA · UniProt Q9BUH6

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