MolNFT v1 · #108767 · protein

Myxovirus resistance protein 2 (mxb)

4WHJ · Interferon-induced GTP-binding protein MX2: “Myxovirus resistance protein 2 (mxb)”. X-ray diffraction, 15 pockets (best druggability 0.67). MolNFT v1 #108767 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4WHJ
Type: protein
Length: 1,130 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interferon-induced GTP-binding protein MX2
UniProt: P20592
Pockets: 15 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 60% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Interferon-induced GTP-binding protein MX2	protein	565	60% helix, 9% strand	P20592

Pockets

15 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	379	0.67	0.80	57	empty
2	209	0.62	0.82	41	empty
3	95	0.57	0.86	30	empty
4	251	0.57	0.78	37	empty
5	235	0.54	0.77	27	empty

Interfaces

1 interface between chains.

A–B · 1049 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

4WHJ · Myxovirus Resistance Protein 2 (MxB) · the same entry in another collection · chain A against A, TM-score 1.00
P20592 · AlphaFold monomer V2.0 prediction for interferon-induced GTP-binding protein MX2 (P20592) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P20592
Elsewhere: RCSB PDB 4WHJ · PDBe 4WHJ · UniProt P20592

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